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Suppliers for
Atazanavir
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Properties | CAS |
198904-31-3 | Formula |
C38H52N6O7 |
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14 Registered suppliers
Molecular Formula: C38H52N6O7 Molecular Weight: 704.87
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Description : Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. - Molecular Weight :704.869
- Melting Point :207-209ºC
- Purity :0.98
Molecular Formula : C38H52N6O7 Canonical SMILES : CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC InChI : InChI=1S/C38H52N6O7/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)/t29-,30-,31+,32+/m0/s1 InChIKey : AXRYRYVKAWYZBR-GASGPIRDSA-N Solubility : In Vitro: DMSO : 166mg/mL(206.74 mM;Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) In Vivo: 1.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution 2.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥≥ 2.5 mg/mL (3.11 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.5 mg/mL (3.11 mM); Clear solution Appearance : Solid powder Storage : Store at -20°C Synonyms : Atazanavir ; Reyataz ; Atazanavir sulfate ; CGP75136 ; CGP75176 ; CGP75355 ; BMS232632 ; CGP 73547 ; CGP 75136 ; CGP 75176 ; CGP 75355 ; CGP-73547 ; CGP-75136 ; CGP-75176 ; CGP-75355 ; BMS 232632 ; BMS-232632 ; BMS-232632-05 ; C413408
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Purity : 98% Smile code : O=C(N[C@H](C(NN(C[C@@H]([C@@H](NC([C@@H](NC(OC)=O)C(C)(C)C)=O)CC1=CC=CC=C1)O)CC2=CC=C(C=C2)C3=NC=CC=C3)=O)C(C)(C)C)OC MDL Number : MFCD08435966 MolFormula : C38H52N6O7 MolWeight : 704.8555 Available in stock : 483.359
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Purity : 98% Smile code : O=C(N[C@H](C(NN(C[C@@H]([C@@H](NC([C@@H](NC(OC)=O)C(C)(C)C)=O)CC1=CC=CC=C1)O)CC2=CC=C(C=C2)C3=NC=CC=C3)=O)C(C)(C)C)OC MDL Number : MFCD08435966 MolFormula : C38H52N6O7 MolWeight : 704.8555 Available in stock : 483.359
More details are to be found here
Purity : 98% Smile code : O=C(N[C@H](C(NN(C[C@@H]([C@@H](NC([C@@H](NC(OC)=O)C(C)(C)C)=O)CC1=CC=CC=C1)O)CC2=CC=C(C=C2)C3=NC=CC=C3)=O)C(C)(C)C)OC MDL Number : MFCD08435966 MolFormula : C38H52N6O7 MolWeight : 704.8555 Available in stock : 483.359
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Atazanavir
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Last update 2024-05-31
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