BGC > Product Search > Pf-06281355 | 1435467-38-1

Description :
PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes.

• Molecular Weight :321.35

Molecular Formula :
C14H15N3O4S
Canonical SMILES :
COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N
InChI :
InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22)
InChIKey :
LJBUZOGABRDGBR-UHFFFAOYSA-N
Solubility :
Soluble to 20 mM in DMSO
Appearance :
Solid powder
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
Synonyms :
2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355.

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