Suppliers for CAS
1144035-53-9
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Properties | CAS |
1144035-53-9 | Formula |
C22H21Cl2N3O5 |
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6 Registered suppliers
Amadis Chemical Company Limited
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C22H21Cl2N3O5 Molecular Weight: 478.32524 WGKGermany: 3
Aea.ltd
P.R.China
Molecular Formula: C22H21Cl2N3O5 Molecular Weight: 478.32524 WGKGermany: 3
BOC Sciences
USA
Description : PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. - Molecular Weight :478.33
- Melting Point :149-150°C
- Purity :≥95%
Molecular Formula : C22H21Cl2N3O5 Canonical SMILES : C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl InChI : InChI=1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29) InChIKey : JMSUDQYHPSNBSN-UHFFFAOYSA-N Solubility : Soluble in DMSO Appearance : White to Beige Tan Powder Storage : Store at -20°C Synonyms : 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
More details are to be found here
Chemlyte Solutions
P.R.China
More details are to be found here
Santa Cruz Biotechnology, Inc.
USA
More details are to be found here
Detailed information on the suppliers of
PF8380
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