BGC > Product Search > KIRA6 | 1589527-65-0

Molecular Formula: C28H25F3N6O
Molecular Weight: 518.55

Molecular Formula: C28H25F3N6O
Molecular Weight: 518.55

Description :
KIRA6 allosterically inhibits IRE1α RNase kinase activity in vivo and promotes cell survival under ER stress. Systemically, KIRA6 preserves pancreatic β cells, increases insulin, and reduces hyperglycemia in Akita diabetic mice.

• Molecular Weight :518.53

Molecular Formula :
C28H25F3N6O
Canonical SMILES :
CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F
InChI :
1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38)
InChIKey :
NOHQEAFAESMMDX-UHFFFAOYSA-N
Solubility :
DMSO: 10 mM
Storage : Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms :
KIRA6; KIRA-6; KIRA 6; 1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea; 1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea; KIRA analog, 2

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