Description :
Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression.
- Molecular Weight :274.228
- Boiling Point :580.2±50.0 °C at 760 mmHg
- Melting Point :265-267ºC
- Purity :98.5%
Molecular Formula :
C14H10O6
Canonical SMILES :
COC1=CC(=C2C(=C1)OC3=C(C=CC(=C3C2=O)O)O)O
InChI :
InChI=1S/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5,15-17H,1H3
InChIKey :
JDIORNFCMMYMLF-UHFFFAOYSA-N
Solubility :
In vitro: 10 mM in DMSO
Appearance :
Yellow powder
Storage : Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 months
Synonyms :
1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one
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