BGC > Product Search > Alsterpaullone | 237430-03-4

Molecular Formula: C16H11N3O3
Molecular Weight: 293.28
Hazard Symbols: Xi
WGKGermany: 3

Description :
Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.

• Molecular Weight :293.3
• Boiling Point :651.53° C at 760 mmHg (Predicted)
• Melting Point :238.72° C (Predicted)
• Purity :≥98%

Molecular Formula :
C16H11N3O3
Canonical SMILES :
O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1
InChI :
InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChIKey :
OLUKILHGKRVDCT-UHFFFAOYSA-N
Solubility :
Soluble to ≥10 mg/ml in DMSO. Insoluble in water and 100% ethanol.
Appearance :
Yellow to Brown Solid
Synonyms :
9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one

More details are to be found here

Description :
Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.

• Molecular Weight :293.3
• Boiling Point :651.53° C at 760 mmHg (Predicted)
• Melting Point :238.72° C (Predicted)
• Purity :≥98%

Molecular Formula :
C16H11N3O3
Canonical SMILES :
O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1
InChI :
InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChIKey :
OLUKILHGKRVDCT-UHFFFAOYSA-N
Solubility :
Soluble to ≥10 mg/ml in DMSO. Insoluble in water and 100% ethanol.
Appearance :
Yellow to Brown Solid
Synonyms :
9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one

More details are to be found here

Description :
Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.

• Molecular Weight :293.3
• Boiling Point :651.53° C at 760 mmHg (Predicted)
• Melting Point :238.72° C (Predicted)
• Purity :≥98%

Molecular Formula :
C16H11N3O3
Canonical SMILES :
O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1
InChI :
InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChIKey :
OLUKILHGKRVDCT-UHFFFAOYSA-N
Solubility :
Soluble to ≥10 mg/ml in DMSO. Insoluble in water and 100% ethanol.
Appearance :
Yellow to Brown Solid
Synonyms :
9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one

More details are to be found here