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Suppliers for CAS
865305-30-2
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Properties | CAS |
865305-30-2 |
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3 Registered suppliers
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C14H17IN4O2 Molecular Weight: 400.21485
Aea.ltd
P.R.China
Molecular Formula: C14H17IN4O2 Molecular Weight: 400.21485
BOC Sciences
USA
Description : AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. - Molecular Weight :400.21
- Boiling Point :510.2±60.0 °C | Condition: Press: 760 Torr
- Purity :> 98%
Molecular Formula : C14H17IN4O2 Canonical SMILES : CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC InChI : InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19) InChIKey : AATPYXMXFBBKFO-UHFFFAOYSA-N Solubility : DMSO: ≥ 32 mg/mL Appearance : Solid powder Storage : -20°C Freezer Synonyms : AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine
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AF-353
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Last update 2024-06-07
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