BGC > Product Search > 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol | 805239-56-9

Molecular Formula: C20H11F6N3O
UN Number: UN 2811 6.1 / PGIII

Description :
PHTPP, a pyrazolo[1,5-α]pyrimidine-based ligand, is a selective estrogen ERβ receptor antagonist that displays 36-fold selectivity over ERα. This compound has been used to selectively target ERβ in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype.

• Molecular Weight :423.31
• Purity :≥99% by HPLC

Molecular Formula :
C20H11F6N3O
Canonical SMILES :
C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F
InChI :
InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
InChIKey :
AEZPAUSGTAHLOQ-UHFFFAOYSA-N
Solubility :
DMSO to 33 mM; ethanol to 100 mM
Appearance :
Yellow solid
Storage : Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms :
4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

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