BGC > Product Search > 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol | 677297-51-7

Molecular Formula: C18H14N6O2
Molecular Weight: 346.3

Molecular Formula: C18H14N6O2
Molecular Weight: 346.3

Description :
TG100-115 is a potent and selective PI3K γ and -δ inhibitor (IC50 values of 83 and 235 nM, respectively) with no effect on PI3Kα or -β (IC50 values > 1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values < 1 μM.

• Molecular Weight :346.35
• Melting Point :> 174ºC (dec.)

Molecular Formula :
C18H14N6O2
Canonical SMILES :
C1=CC(=CC(=C1)O)C2=NC3=C(N=C2C4=CC(=CC=C4)O)N=C(N=C3N)N
InChI :
InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
InChIKey :
UJIAQDJKSXQLIT-UHFFFAOYSA-N
Appearance :
Yellow Solid
Synonyms :
TG100115; TG-100115; TG 100115; TG-100-115; TG100-115 ; TG 100-115. 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine; 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol

More details are to be found here

Description :
TG100-115 is a potent and selective PI3K γ and -δ inhibitor (IC50 values of 83 and 235 nM, respectively) with no effect on PI3Kα or -β (IC50 values > 1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values < 1 μM.

• Molecular Weight :346.35
• Melting Point :> 174ºC (dec.)

Molecular Formula :
C18H14N6O2
Canonical SMILES :
C1=CC(=CC(=C1)O)C2=NC3=C(N=C2C4=CC(=CC=C4)O)N=C(N=C3N)N
InChI :
InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
InChIKey :
UJIAQDJKSXQLIT-UHFFFAOYSA-N
Appearance :
Yellow Solid
Synonyms :
TG100115; TG-100115; TG 100115; TG-100-115; TG100-115 ; TG 100-115. 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine; 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol

More details are to be found here

Description :
TG100-115 is a potent and selective PI3K γ and -δ inhibitor (IC50 values of 83 and 235 nM, respectively) with no effect on PI3Kα or -β (IC50 values > 1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values < 1 μM.

• Molecular Weight :346.35
• Melting Point :> 174ºC (dec.)

Molecular Formula :
C18H14N6O2
Canonical SMILES :
C1=CC(=CC(=C1)O)C2=NC3=C(N=C2C4=CC(=CC=C4)O)N=C(N=C3N)N
InChI :
InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
InChIKey :
UJIAQDJKSXQLIT-UHFFFAOYSA-N
Appearance :
Yellow Solid
Synonyms :
TG100115; TG-100115; TG 100115; TG-100-115; TG100-115 ; TG 100-115. 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine; 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol

More details are to be found here