BGC > Product Search > 2-(4-tert-Butylphenyl)benzimidazole | 49671-76-3

Molecular Formula: C17H18N2
Molecular Weight: 250.33822
Hazard Symbols: Xn
WGKGermany: 3

Molecular Formula: C17H18N2
Molecular Weight: 250.33822
Hazard Symbols: Xn
WGKGermany: 3

Description :
Selective transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 selectively stimulated the expression of PGC-1α and downstream genes in skeletal muscle cells, and led to changes in glucose uptake, and fatty acid oxidation in L6 myotubes in a AMPK dependent manner. Since ZLN 005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes, it is hypothesized that expression of PGC-1α was regulated in a cell type-specific manner. ZLN005 exerts promising therapeutic effects for treating type 2 diabetes, as PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, a crucial player in the field of glucose uptake in skeletal muscle.

• Molecular Weight :250.34
• Purity :> 98%

Molecular Formula :
C17H18N2
Canonical SMILES :
CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2
InChI :
InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)
InChIKey :
LQUNNCQSFFKSSK-UHFFFAOYSA-N
Synonyms :
ZLN005; ZLN-005; ZLN 005.

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